Gamma globulin metabolism in rabbits immunized with autologous denatured gamma globulin

Sensitization to Denatured Autologous Gamma Globulin

Immunization of guinea pigs with denatured autologous gamma globulin results in the development of delayed hypersensitivity to some form of gamma globulin. When the autologous gamma globulin is subjected to denaturation with alkaline treatment as employed in this study, guinea pigs regularly develop reactivity to the immunizing material and occasionally to some form of heterologous gamma globul...

Gamma Globulin Metabolism in Rabbits during the Anamnestic Response

1. Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I(131) 24 times in 13 control rabbits. Similar studies were performed before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine. 2. During the ananmestic response, gamma-globulin levels increased from 1.0 to 6.0 gm/100 ml, and the gamma-globul...

Human Gamma Globulin.

Gamma globulin prophylaxis.

THE importance of infectious hepatitis as a world-wide problem has been highlighted in detail during the presentations made at this symposium. It is clear that as of today (May I 8, I968) there is no published report confirming the isolation of infectious hepatitis virus in a tissue-culture system or animal host. Experience with poliomyelitis, measles, and rubella has revealed that the time int...

Gamma Globulin and Antibody Formation in Vitro I. Gamma Globulin Formation in Tissues from Immature and Normal Adult Rabbits*,

Studies on antibody formation "in vitro" have supplied information concerning the site of antibody production (1-5), the rates of antibody synthesis per unit weight of tissue (6-7) and the percentage of active cells in lymphoid tissue during the primary and secondary antibody response (8-9). In vitro experiments have also been used in attempts to elucidate the mechanism of induction of antibody...